Peripheral thromboembolic events included (Median Follow-up 96 Months; Median Treatment 60 Months). drugs or dietary management of elevated lipids was allowed [see WARNINGS AND PRECAUTIONS]. Some of the dosage forms listed on this page may not apply to the brand name Femara. Side effects are often predictable in terms of their onset and duration. Table 1 describes adverse reactions (Grades 1-4 and (11.4%) regarding fractures. Femara is available in generic form. However, a number of side effects with letrozole are more serious and should be reported immediately to a healthcare provider. patients who received Femara 6.9% (176) than in patients who received placebo 5.5% (141). discontinuations for reasons other than progression occurred in 6/193 (3.1%) on 0.5 mg Femara, 7/185 (3.8%) on 2.5 mg Femara, and Femara is used mainly in women after menopause. Adverse reactions that were reported in at least 5% of the patients treated with Femara 2.5 mg or tamoxifen 20 mg in the first-line It may harm a fetus. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Medically reviewed by Drugs.com. Femara (letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen Note: This document contains side effect information about letrozole. overall the side effects seen were consistent to those seen at a median treatment duration of 24 months. reactions were bone pain, hot flushes, back pain, nausea, arthralgia and dyspnea. It is unknown if this drug passes into breast milk and may harm a nursing infant. Serious allergic reaction. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies, round, yellow, imprinted with APO, LET 2.5. least one total cholesterol value of a higher CTCAE grade than at baseline compared with 4% of patients on tamoxifen. The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. There were However, most side effects women face are usually when they take letrozole to treat cancer – you take letrozole for only five days to treat infertility. Decreased Calcification Or Density Of Bone. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication. Most adverse reactions reported were Grade 1 and Grade 2 based on the CTC Version 2.0. Common side effects of letrozole include: aching or pain in the joints or muscles ; menopausal symptoms ; low mood and depression ; difficulty sleeping ; fatigue ; osteoporosis ; high blood pressure and cholesterol The following adverse reactions were also identified in less than 5% of the 2049 patients treated with letrozole and not included in Note: This document contains side effect information about letrozole. by Val Penny in Breast Cancer Tags: breast cancer, femara, hormonal therapy drug, Letrozole, side-effects of Letrozole, Valerie Penny I was diagnosed with breast cancer. 2.0/Common Terminology Criteria for Adverse Events (CTCAE), Version 3.0. endometrial hyperplasia/cancer (0.3% vs 2.9%), and endometrial proliferation disorders (0.3% vs 1.8%) (Femara vs Other side effects include: myalgia. Based on a median follow-up of patients for 28 months,the incidence of clinical fractures from the core randomized study in patients Femara can cause fetal harm during pregnancy. Read the entire detailed patient monograph for Femara (Letrozole). Still, it is possible to experience some side effects such as dizziness, fatigue, bloating, headache, hot … The incidence of self-reported osteoporosis was higher in © Femara Patient Information is supplied by Cerner Multum, Inc. and Femara Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Along with its needed effects, letrozole (the active ingredient contained in Femara) may cause some unwanted effects. If you have recently gone through menopause, discuss birth control with your doctor. were reported were cataract, eye irritation, palpitations, cardiac failure, tachycardia, dysesthesia (including hypesthesia/paresthesia), Side effects of letrozole . There was also less vaginal Common side effects of Femara include: bone fracture, arthralgia, edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and flushing. There are many options to help minimize or prevent side effects. A higher incidence was seen for tamoxifen regarding thromboembolic events (2.1% vs 3.6%), When considering all grades during study treatment, a higher incidence of events was seen for Femara regarding Bone fracture breast pain chest pain chills, fever, or flu-like symptoms mental depression swelling of the feet or lower legs Rare. This side effect can be very troubling for some women. Additional side-effect profiles were collected. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for LETROZOLE. pain in the chest, groin, or legs, especially the calves, severe and sudden, unexplained troubled breathing, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, sores, ulcers, or white spots on the lips or in the mouth, Bad, unusual, or unpleasant (after) taste and thirst. Call your doctor for medical advice about side effects. When letrozole is given. O 0. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. arterial thrombosis, memory impairment, irritability, nervousness, urticaria, increased urinary frequency, leukopenia, stomatitis Cerner Multum, Inc. "UK Summary of Product Characteristics." disorders*, * Target events pre-specified for analysis. What is Femara (letrozole) and what is it used for? Bone pain, joint pain or muscle ache; Hot flushes can sometimes occur If this occurs, take your tablets at bedtime. Preferred Term (Safety set). In study MA-17, the median duration of extended adjuvant treatment was 24 months and the median duration of follow-up for fewer thromboembolic events at both Femara doses than on the megestrol acetate arm (0.6% vs 4.7%). Femara(Letrozole) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. Lipid Substudy: In the extended adjuvant setting, based on a median duration of follow-up of 62 months, there was no significant Arimidex (anastrozole) and Femara (letrozole) are non-steroidal aromatase inhibitors (lowers estrogen production) used to treat breast cancer in postmenopausal women. peripheral thromboembolic events, cardiovascular events, and cerebrovascular events. These are not all the side effects of letrozole. of postmenopausal women with hormone receptor and node positive breast cancer (FACE, NCT00248170), the median The majority of the data on the side effects of Letrozole come from women who use it as part of a five-year cancer treatment regimen. Table 1: Patients with Adverse Reactions (CTC Grades 1-4,) in the Adjuvant Study – Monotherapy Arms Analysis The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. asthenia)*, Endometrial proliferation Serious side effects are rare and happen in less than 1 in 100 people. Side effects are often predictable in terms of their onset and duration. Femara groups in either study. Other drugs may interact with Femara. In the extended adjuvant During treatment or within 30 days of stopping treatment (median duration of treatment 60 months) a higher rate of fractures was Copyright © 2021 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of new Common side effects of Femara include nausea, vomiting, fatigue, headache, muscle aches, diarrhea, constipation, and chest pain. 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